Klug Lab Awarded SPARK Grant for Groundbreaking Hearing Restoration Research

Research team receives funding to advance innovative solutions for age-related hearing loss

The Klug Laboratory has been awarded a prestigious SPARK Grant from the State of Colorado Office of Economic Development and International Trade (OEDIT) Advanced Industries grant program. This award will accelerate the translation of the lab's research on hearing restoration into marketable solutions that address one of the most common challenges of age-related hearing loss.

  • Bridging Research and Real-World Application

    Age-related hearing loss affects millions of people worldwide, with one of its most debilitating aspects being the difficulty in following conversations in noisy environments. Unlike conventional hearing loss that simply reduces volume, this specific form of impairment—often called the "cocktail party problem"—compromises a person's ability to distinguish between competing sounds, making social gatherings particularly challenging.

    The Klug Lab's approach targets the neural mechanisms responsible for auditory signal processing, offering hope for those who struggle with speech comprehension in crowded settings. The SPARK Grant will provide crucial resources to bridge the gap between laboratory research and commercial applications, potentially transforming how this form of age-related hearing loss is treated.

    From Laboratory to Marketplace

    This support from Colorado's Advanced Industries grant program will be transformative. While traditional hearing aids amplify all sounds, this new technology specifically addresses the brain's diminished capacity to filter and focus on relevant speech in noisy environments—a capability that naturally declines with age.

    The OEDIT Advanced Industries grant program was designed precisely for initiatives like this—supporting research with clear commercial potential that can strengthen Colorado's position in innovative industries while addressing significant health challenges.

    The lab will now begin the process of developing prototypes and conducting targeted trials necessary to bring their technology to market, potentially creating new jobs in Colorado's growing biotechnology sector.

    Looking Ahead

    As the lab moves forward with commercialization efforts, their work stands to benefit an aging population increasingly affected by communication difficulties in social settings. For millions who have withdrawn from social interactions due to hearing challenges, this technology represents more than just medical innovation—it offers the possibility of renewed connection and improved quality of life.

    The SPARK Grant's support of this hearing restoration technology exemplifies the important role that targeted public funding can play in advancing solutions to pressing health challenges while simultaneously fostering economic development in Colorado's advanced industries. The official start date of this two year project is May 1, 2025.

The Silent Threat: Why Treating Hearing Loss Matters for Healthy Aging

In the quest for healthy aging, we often focus on diet, exercise, and mental stimulation. Yet one critical factor frequently goes unaddressed: hearing loss. Research increasingly shows that untreated hearing loss isn't just an inconvenience—it's actually the largest modifiable risk factor for healthy aging, with far-reaching consequences beyond simply missing parts of conversations.

  • Understanding the Ripple Effect

    When hearing begins to fade, it doesn't occur in isolation. The impacts cascade through multiple aspects of life:

    Cognitive Decline and Dementia Risk

    Perhaps most alarming is the strong link between untreated hearing loss and cognitive decline. Studies show that individuals with untreated hearing loss experience a faster rate of cognitive decline and face up to a 5 times higher risk of developing dementia, including Alzheimer's disease.

    Why does this happen? When your brain constantly struggles to interpret sounds and speech, it redirects resources from other cognitive functions. This "cognitive load" theory means your brain works harder on basic hearing tasks, leaving fewer resources for memory and other cognitive processes.

    Social Isolation and Loneliness

    When conversation becomes challenging, many people begin to withdraw from social activities. Dinners at restaurants become frustrating exercises in strain and embarrassment. Phone calls turn into guessing games. Eventually, many choose to avoid these situations altogether.

    This withdrawal leads to isolation, which research has identified as a major health risk. The loneliness that follows isn't just emotionally painful—it's physically damaging.

    Depression and Mental Health

    The combination of communication difficulties and social isolation creates fertile ground for depression. Studies show people with untreated hearing loss have significantly higher rates of depression, anxiety, and stress. Mental health struggles further compromise quality of life and can accelerate other health issues.

    A Preventable Cascade

    What makes these connections particularly tragic is that they're largely preventable. Unlike many age-related changes, hearing loss can typically be addressed effectively with proper interventions:

    • Hearing aids have evolved dramatically from the bulky devices of the past. Today's options are often nearly invisible, with sophisticated technology that filters background noise and enhances speech.

    • Cochlear implants can help those with more severe hearing loss that hearing aids cannot adequately address.

    • Assistive listening devices can help in specific situations like watching television or talking on the phone.

    Overcoming Hesitation

    Despite these solutions, many resist addressing their hearing loss. The average person waits seven years after first noticing hearing problems before seeking help. Common barriers include:

    • Stigma: Concerns about appearing "old" or disabled

    • Denial: Believing the problem isn't serious or affects others more than themselves

    • Cost concerns: Worries about the expense of hearing technology

    • Previous bad experiences: Outdated impressions of hearing aid effectiveness

    Taking Action for Healthy Aging

    If you've noticed changes in your hearing—perhaps turning up the TV volume, frequently asking people to repeat themselves, or struggling to follow conversations in noisy environments—consider these steps:

    1. Get a baseline hearing test, even if you don't think you have a problem. Early detection means earlier intervention.

    2. Discuss results with hearing professionals who can explain your options without pressure.

    3. Give adjustment time if you do need hearing aids. Like any new technology, there's a learning curve, but persistence pays off.

    4. Remember the stakes – this isn't just about hearing better; it's about protecting your cognitive health, emotional wellbeing, and social connections.

    Conclusion

    In our pursuit of healthy aging, addressing hearing loss represents low-hanging fruit—a modifiable risk factor with effective solutions already available. By overcoming hesitation and seeking appropriate treatment, we can potentially reduce risk for dementia, depression, and social isolation while improving overall quality of life.

    Don't let untreated hearing loss silently shape your future. The conversation you save may be much more than social—it might be your cognitive health, your emotional wellbeing, and ultimately, your independence as you age.

    [This blog post is for informational purposes only and is not intended as medical advice. Please consult healthcare professionals regarding your specific health concerns.]

Age-Related Hearing Loss: What Happens in the Ear as We Age

As we journey through life, our bodies undergo countless changes, and our ears are no exception. Age-related hearing loss, medically known as presbycusis, affects millions of older adults worldwide. While many people accept hearing difficulties as an inevitable part of aging, understanding what actually happens inside the ear can help us better address and treat these changes.

  • The Delicate Architecture of Hearing

    Our ability to hear depends on an intricate system within the inner ear, particularly within a snail-shaped structure called the cochlea. Inside the cochlea are thousands of tiny hair cells that serve as sensory receptors. These microscopic cells are responsible for converting sound vibrations into electrical signals that travel to the brain.

    These hair cells are remarkable but vulnerable structures. Unlike many cells in our body, cochlear hair cells cannot regenerate once damaged or destroyed. This permanent nature of hair cell loss is at the heart of most age-related hearing problems. As you can imagine, many research groups are trying very hard to find medical treatments that would regenerate these hair cells during a listener’s lifetime, but this challenge turns out to be much more difficult than anticipated. There is no such treatment to date and there is none that is just around the corner. This is especially perplexing since many vertebrate animals can regenerate these hair cells, such as birds, lizards and others. It’s just the mammals that lost this ability which is why scientists initially thought this problem should be pretty easy to solve.

    The Progression of Age-Related Hearing Loss

    One of the most common patterns in age-related hearing loss is that it typically begins with difficulty hearing high-frequency sounds. This is why many older adults might report:

    • Trouble understanding women's and children's voices, which tend to be higher-pitched

    • Difficulty distinguishing consonant sounds like "s," "f," "th," and "ph"

    • Problems hearing birds chirping or electronics beeping

    This pattern occurs because the hair cells that detect higher-frequency sounds are located at the base of the cochlea, where sound enters first. These cells endure more "wear and tear" over a lifetime and often deteriorate first.

    Why Do Hair Cells Die?

    Several factors contribute to the gradual loss of cochlear hair cells:

    1. Cumulative noise exposure: A lifetime of sound exposure, even at moderate levels, can damage hair cells over time

    2. Reduced blood flow: Age-related vascular changes can reduce blood supply to the inner ear

    3. Genetic predisposition: Family history plays a significant role in determining susceptibility

    4. Oxidative stress: Free radical damage accumulates in the cochlea over time

    5. Medical conditions: Diabetes, heart disease, and certain medications can accelerate hair cell loss

    Again, once these delicate cells die, the loss is permanent with current medical technology. This irreversible nature makes prevention particularly important.

    Effective Treatment Through Hearing Aids

    The good news is that modern hearing aids can effectively treat most cases of age-related hearing loss. Today's hearing aids are technological marvels compared to devices from even a decade ago:

    • Digital processing allows for precise amplification of specific frequencies

    • Directional microphones help focus on conversation in noisy environments

    • Connectivity features enable direct streaming from phones and other devices

    • Rechargeable batteries eliminate the hassle of tiny battery replacements

    • Nearly invisible designs address aesthetic concerns

    Many users report significant improvements in quality of life after being properly fitted with appropriate hearing devices. The key is early intervention—addressing hearing loss before the brain begins to lose its ability to process certain sounds.

    Beyond the Ear: Age-Related Changes in the Brain

    While this article has focused on the ear-level changes in age-related hearing loss, it's important to recognize that hearing happens in the brain, not just the ear. In fact, there's another type of hearing loss that affects many older adults: central auditory processing disorder.

    This brain-based hearing difficulty involves how the central auditory system processes sound information. Even when sounds are detected by healthy hair cells and transmitted through intact auditory nerves, the brain may struggle to make sense of what's being heard. This can manifest as difficulty understanding speech in background noise, following rapid speech, or locating the source of sounds—even when standard hearing tests show relatively normal results. A future blog post will discuss this question.

    [This blog post is for informational purposes only and is not intended as medical advice. Please consult healthcare professionals regarding your specific health concerns.]

New Publication Alert: Klug Lab Unveils Novel Sapphire Optrode in International Collaboration

In an exciting development for neuroscience research, the Klug Lab has published a new paper detailing an innovative sapphire optrode that promises to enhance optogenetic experiments. This work represents an international collaboration between research teams from Macau, Guangzhou, UC Denver, and the Klug Lab at CU Anschutz.

  • A Transparent Yet Durable Solution

    The newly developed device combines neural recording capabilities across multiple channels with precise light stimulation through miniature LEDs embedded directly in a sapphire substrate. What makes this optrode particularly remarkable is the sapphire material itself—transparent like glass but with exceptional hardness that enhances both safety and targeting accuracy during experiments.

    Flexible Design for Customized Research

    One of the most significant advantages of this new technology is the ability to arrange recording sites and LED locations in arbitrary configurations. This flexibility will allow researchers in the future to customize the optrode layout for specific experimental requirements, potentially opening doors to novel experimental paradigms that were previously impossible to implement.

    Enhancing Optogenetic Research

    For those working in optogenetics—a technique that uses light to control cells in living tissue, typically neurons that have been genetically modified to express light-sensitive ion channels—this development represents a substantial leap forward. The integration of both recording and stimulation capabilities in a single, highly durable probe will enable more sophisticated experiments with greater precision.

    The combination of multi-channel neural recording with targeted light delivery through integrated LEDs addresses a critical challenge in the field: simultaneous stimulation and recording at precise locations in neural tissue.

    Citation:

    Yanyan Xu, Ben-Zheng Li, Xinlong Huang, Yuebo Liu, Zhiwen Liang, Xien Yang, Lizhang Lin, Liyang Wang, Yu Xia, Matthew Ridenour, Yujing Huang, Zhen Yuan, Achim Klug, Sio Hang Pun, Tim C. Lei, Baijun Zhang:

    Sapphire-Based Optrode for Low Noise Neural Recording and Optogenetic Manipulation

    ACS Chemical Neuroscience Vol 16, 628-641, 2025.

    https://pubs.acs.org/doi/10.1021/acschemneuro.4c00602

Dr. Benzheng Li Awarded Prestigious Hearing Health Foundation Emerging Research Grant

We are excited to announce that Dr. Benzheng Li has been awarded a Hearing Health Foundation Emerging Research Grant for his innovative work in computational neuroscience.

  • Dr. Li's research focuses on developing complex mathematical models and neural decoders to explore the neural mechanisms behind sound localization. His work bridges the gap between theoretical neuroscience and hands on experimental approaches, potentially leading to improved hearing technologies and interventions.

    The Hearing Health Foundation's Emerging Research Grant program supports promising scientists in the early stages of their careers who demonstrate exceptional potential to advance our understanding of hearing disorders. This competitive grant will provide crucial funding for Dr. Li to continue his groundbreaking work.

    This grant represents an important opportunity to advance our understanding of how the brain processes spatial auditory information. By developing more accurate models of neural circuits involved in sound localization, better treatments for those with hearing impairments can be facilitated.

    Dr. Li's interdisciplinary approach combines computational modeling, signal processing, and neuroscience wet alb approaches to understand the neural activity patterns associated with hearing in noise processing. His research has implications not only for hearing health but also for broader applications in neural engineering and sensory augmentation technologies.

    For more information about Dr. Li and this award, visit:

    https://hearinghealthfoundation.org/meet-the-researcher/ben-zheng-li-2025